Since june 2012, twelve infections were treated with postdialysis cefepime in 9. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and. Peritoneal dialysis for continuous ambulatory peritoneal dialysis capd, administer recommended doses of cefepime as indicated for the infection and extend the dosing interval to every 48 hours. However, this medicine will not work for colds, flu, or other virus infections.
Pediatric drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in psychiatry. Cefepime neurotoxicity in patients with renal insufficiency. Oct 02, 2018 maxipime can pass into breast milk and may harm a nursing baby. It works by killing bacteria or preventing their growth. Food and drug administration fda is reminding health care professionals about the need to adjust the dosage of the antibacterial drug cefepime in patients with renal kidney impairment. Cefepime is the generic form of the brandname drug maxipime, which is used to treat bacterial infections such as urinary tract infections, pneumonia, and skin infections the prescription. Renal dose adjustment guidelines for antimicrobials crrt.
Find patient medical information for maxipime injection on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. It is administered intravenously through a vein or by injection into a. A maxipime vial contains 500 mg, 1g or 2g of cefepime activity in the form of a sterile mix of cefepime dihydrochloride monohydrate and larginine. Threetimesweekly, postdialysis cefepime therapy in. Maxipime cefepime hydrochloride, usp is a semisynthetic, broad spectrum, cephalosporin antibiotic for parenteral administration. This book is distributed under the terms of the creative commons. Maxipime cefepime dosing, indications, interactions. Cefepime drug monograph pediatric care online aap pointof. Maxipime is contraindicated in patients who are hypersensitive to this drug or other cephalosporin or penicillin antibiotics. Cefepime is a broadspectrum fourthgeneration cephalosporin with in vitro activity similar to that of cefotaxime or ceftriaxone against the common meningeal pathogens h. Maxipime cefepime hydrochloride, usp for injection for.
Jul 09, 2015 cefepime is a cephalosporin antibacterial drug used to treat pneumonia, urinary tract, skin, and intraabdominal infections. Cefepime cep is approved by the food and drug adminstration fda for the treatment of febrile neutropenia, empiric therapy of uncomplicated skin and soft tissue infection ssti, complicated intra. In patients with renal impairment in patients who have creatinine clearance less than 60 ml min dose of this drug must be reduced. Side effects of maxipime cefepime hydrochloride for. Renal dose adjustment guidelines for antimicrobials. Cefepime injection may cause diarrhea, and in some cases it can be severe. Cefepime for injection should be administered at the same time each day and following the completion of hemodialysis on hemodialysis days. This is not a complete list of side effects and others may occur. Find patient medical information for maxipime intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. To reduce the development of drugresistant bacteria and maintain the effectiveness of maxipime and other antibacterial drugs, maxipime should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. Precautions must be taken in the following situations.
This effect is increased when you also use certain other medicines, including. Cefepime belongs to antibiotics, used in the treatment of infections. By continuing to browse this site you are agreeing to our use of cookies. Dosage adjustment may be required in cases of impaired renal. The recommended doses of maxipime in patients with renal impairment are presented in table 2. Renal dosage adjustment guidelines for antimicrobials the. Detailed cefepime dosage information for adults and children. When selecting an antimicrobial dosing regimen for critically ill patients with severe renal failure, the effects of renal failure itself, other acute and chronic disease states, and extracorporeal drug clearance by renal replacement therapies on drug pharmacokinetics should be considered. Includes dosages for bacterial infection, urinary tract infection, pneumonia and more. Medscape indicationspecific dosing for maxipime cefepime. A 2007 metaanalysis suggested when data of trials were combined, mortality was increased in people treated with cefepime compared with other. Cut cefepime dose in kidney disease fda says medpage today. Maxipime 2 g injection composition maxipime cefepime hydrochloride for injection is a cephalosporin antibiotic intended for intramuscular or intravenous administration. The dosage of cefepime for injection for hemodialysis patients is 1 g on day 1 followed by 500 mg every 24 hours for the treatment of all infections except febrile neutropenia, which is 1 g every 24 hours.
When a patient is initiated on crrt, antimicrobial therapy often requires adjustment to ensure adequate drug concentrations are achieved. Cefepime cep is approved by the food and drug adminstration fda for the treatment. Dosage adjustments in patients with renal impairment. Nov 01, 2019 maxipime for injection is supplied for intramuscular or intravenous administration in strengths equivalent to 500 mg, 1 g, and 2 g of cefepime. Renal department peritoneal dialysis service workplace instruction approved by. Your specific cefepime dosage will depend on how much you weigh and the purpose for using the medication, among other factors. Ibm micromedex if your symptoms do not improve within a few days, or if they become worse, check with your doctor. Carboplatin, carmustine, caspofungin, cefaclor, cefadroxil, cefazolin, cefdinir, cefepime, cefotaxime, cefotetan, cefotiam, cefoxitin, cefprozil, ceftazidime. Cvvhd removes solutes including drugs via diffusion. For children, the dosage is calculated based on the childs weight. Oct 02, 2018 maxipime for injection is supplied for intramuscular or intravenous administration in strengths equivalent to 500 mg, 1 g, and 2 g of cefepime.
The larginine, at an approximate concentration of 707 mgg of cefepime, is added to control the ph of the constituted. Adjust the dose of maxipime in patients with creatinine clearance less than or equal to 60 mlmin to compensate for the slower rate of renal elimination. The dose requires adjustment for patients with renal dysfunction, defined as. Nov 27, 2019 adjust the dose of maxipime in patients with creatinine clearance less than or equal to 60 mlmin to compensate for the slower rate of renal elimination. Our maxipime side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication. The st george hospital renal department peritoneal dialysis committee date.
Maxipime cefepime hydrochloride injection, powder, for. Guidelines recommend cefepime plus vancomycin, gentamicin, and rifampin if prosthetic material is present for culturenegative nosocomial endocarditis associated with vascular cannulae or early less than 1 year after surgery prosthetic valve endocarditis. It belongs to the class of medicines known as cephalosporin antibiotics. Cefepime dosage forms include injection and infusion, and should be administered only by health care team. Cefepime is a topic covered in the johns hopkins abx guide to view the entire topic, please sign in or purchase a subscription official website of the johns hopkins antibiotic abx, hiv, diabetes, and psychiatry guides, powered by unbound medicine.
The standard recommended amount is 50 mg per kg about 22. Cefepime has an extended spectrum of activity against grampositive and gramnegative bacteria, with greater activity against both types of organism than thirdgeneration agents. The initial dose of cefepime for patients with renal impairment is the same as for patients with normal renal function. Pharmacokinetic and pharmacodynamic parameters were calculated using samples obtained. Maxipime injection is used to treat bacterial infections in many different parts of the body. Cefepime is a fourthgeneration cephalosporin with a broad spectrum of action in monotherapy. In hemodialysis patients, postdialysis treatment with intravenous antibiotics permits even severe infections to be managed on an outpatient basis. We report on the pharmacokinetics of cefepime in postdialysis therapy. Maxipime is approved for use in children as young as two months old. Risk may be increased in the presence of renal impairment.
Pdf pharmacokinetics and pharmacodynamics of cefepime in. Maxipime reference guide for safe and effective use from the american society of. Feb 29, 2012 cefepime is excreted mostly via glomerular filtration, and its neurotoxicity has been reported mainly in patients with renal insufficiency. Cefepime is a newer cephalosporin of iv generation and works against a wide range of bacteria. Pharmacokinetics of cefepime during continuous renal. If your kidneys do not function well, you may need a lower and less frequent amount. Cefepime is a drug from the group of medicines called cephalosporins. Maxipime fda prescribing information, side effects and uses. Maxipime and other antibacterial drugs, maxipime should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
Renal functionbased dose adjustments adult inpatient. The most current version of the renal dosage adjustment guidelines for antimicrobials and associated. This document outlines renal function based dose adjustments for adult inpatients and outpatients with renal impairment who are receiving oral and parenteral medications, with the exception of medications defined as chemotherapy for. Maxipimetm cefepime hydrochloride, usp for injection. Maxipime cefepime dosing, indications, interactions, adverse. Cefepime hydrochloride is a fourthgeneration cephalosporin that belongs to. Jun 27, 2012 the antibiotic cefepime maxipime may cause a specific type of seizure in patients with kidney impairment when doses are not reduced appropriately, the fda warned. Mild to moderate uncomplicated or complicated infections. In these patients, the recommended initial dose of maxipime should be the same as in patients with crcl greater than 60 mlmin except in patients undergoing hemodialysis. Cefepime maxipime side effects, dosage, interactions drugs. Maxipime cefepime hydrochloride dose, indications, adverse. Cefepime is given as an intravenous or intramuscular injection, usually once every 8 or 12 hours. Uncomplicated skin and skin structure infections, bone and joint infections, uncomplicated. Jun 26, 2012 information on cefepime marketed as maxipime share.